The interface between electronic circuits and life sciences is one of the focal points of future integrated system design. Applications include biomolecule detection, biosensor arrays, deep brain stimulation, cardiac cell monitoring, among many others. Several solutions for electronic devices/biological matter interactions are already available and they have proven their potential to be highly- portable systems or high-throughput systems or both. In this tutorial, we will address in detail the challenges in design and implementation of electronic sensors, circuits and systems as privileged means to interact with biological matter while bringing the advantage of almost unlimited choice of signal processing, storing and communication solutions. All aspects will be covered, ranging from providing an overview of different sensing solutions, discussing the architectural and circuit design issues to illustrating the packaging and testing solutions for both in vitro and in vivo applications. The tutorial scope goes from advanced research to commercial applications that are available on the market.